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Unfortunately, aging has a genetic factor to it. Meaning if you are lucky in the genetic lottery you will age much slower than others, if you are unlucky you will age much faster.

Research has proven that some people age a lot quicker than others, up to three times faster. The aging happens faster both internally and externally for some people, meaning signs of aging turn up a lot quicker, even in later 20s or early 30s.

Brain function is one area where degradation can happen as early as 30 years before dementia can even be detected. 

I am one of those people who have been experiencing premature brain aging, with abnormally high levels of fatigue, forgetfulness and brain fog for my age. My mental capacity and speed has significantly diminished since hitting the age of 30 and have been on a downward slope. I also show signs of accelerated early aging, but I will mainly focus on the brain here.

It turns out, some unlucky people may actually experience a much faster degradation of brain function to people with good genetics. I also found out that Keto Supplements may be key to both sustaining brain performance and preventing permanent damage done. 

Though not conclusive, Dementia patients have reduced glucose intake in the brain, some research suggests that this may have been happening for a long time leading to brain atrophy. Early aging may be cutting off glucose to the brain, thus causing a circular effect. The hypothesis is that dementia is literally caused by the atrophy of the brain.

A lack of glucose because of early aging also means lower executive functions in the prefrontal cortex following the "resources" hypothesis of willpower. Some people are very sharp at the age of 60 but some people already can't function normally at the age of 60. This is variance of aging depending on your genetics.

This is where Mild Ketonemia comes in.

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“This research makes an argument that that impaired brain glucose metabolism may be a contributing factor to the development of Alzheimer's Disease, though it also says it's possible that it's AD that is causing the decrease in glucose uptake. They present evidence that it is glucose uptake that causes brain atrophy first, way before symptoms even start to show (affecting cognitive reserve). They finally suggest Milk Ketonemia as a solution to accelerated aging.

BRAIN FUEL METABOLISM, AGING AND ALZHEIMER’S DISEASE

Lower brain glucose metabolism is present before the onset of clinically-measurable cognitive decline in two groups of people at risk of Alzheimer’s disease (AD) ...these reports suggest that brain hypometabolism may precede and contribute to the neuropathological cascade leading cognitive decline in AD. The reason for brain hypometabolism is unclear but may include defects in glucose transport at the blood-brain barrier, glycolysis, and/or mitochondrial function. .... Nevertheless, aging appears to increase the risk of deteriorating systemic control of glucose utilization which, in turn, may increase the risk of declining brain glucose uptake, at least in some regions.

“Evidence that MCT supplement will work to increase plasma ketones.

Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: Estimated potential contribution to brain energy metabolism

Conclusions

This MCT supplementation protocol was mildly and safely ketogenic and had no side effects in healthy humans on their regular diet. This degree of ketonemia is estimated to contribute up to 8% to 9% of brain energy metabolism.

Why Does The Brain Get More Fatigued As We Age?

The speculation from the research  (backed up with evidence) - is that as glucose metabolism changes with age, to get sufficient fuel the brain may be forced into a corner and rely on an option called catabolic gluconeogenesis. Since there isn't enough glucose getting into the brain, the only option is to forcefully burn glucose that is endogenous in the brain.

This is an emergency solution, in the long run the energy deficit becomes huge. Eventually when it goes long enough brain regions will become fatigued due to finally exhausting even their internal supply of glucose. Essentially this is cellular starvation. (R)

Interestingly, the Hippocampus is one of the most vulnerable regions to this fuel deficit, which is associated with the neurodegenerative changes and functioning decline of Alzeihmers as well as PTSD and depression.

Impaired brain glucose metabolism is particularly bad for people with a genetic predisposition to AD the gene (apoE4).

This can happen without serious incidents for 30 and more years before memory problems even start to appear. This is bad because it means that brain degradation caused by this gene defect and accelerated aging can actually be happening over decades without any sign of serious problems, but only increasingly tired and easily over taxed brain.

Reduced brain activity may actually be a protective mechanism in the face of brain starvation.

Ketones - Brain Fuel Alternative to Glucose

The uptake of ketones in an aging brain remains consistent, which makes supplementing ketones a possible solution to delay aging related fatigue. (R)

Glycolysis is impaired in the AD brain, but metabolic rate of ketones and metabolic capacity are not affected. (R) (R)

The brain is fully capable of converting ketones into ATP. That said, ketones cannot fully replace glucose as brain fuel, as glucose is essential for the brain as the precursor to lactate, as well as providing the carbon to replace oxaloacetate in the tricarboxylic acid cycle.

Several studies show the mild ketonemia can maintain normal brain function even when plasma glucose is so low, that it would cause cognitive problems.

Whilst the brain can use fatty acids, the blood-brain barrier is too slow to make it a useful alternative.

As ketosis is triggered ketones can provide roughly 60% of the brain's energy requirements.

Raising plasma ketone levels also increase cerebral blood flow in humans, which may contribute to their beneficial effects on human cognition.

The relatively fast onset of a ketone supplement suggests a fairly direct mode of action improving energy supply to the brain, restoring cognitive function.

It is unknown whether long-term supplementation of ketones will actually result in slower brain decline, but going by the hypothesis that hypometabolism is causing irreversible damage-over-time, it is likely that supplementing with ketones will at the very least prevent this particular mechanism from prematurely aging the brain.

On top of this, there are obvious benefits to keto supplements without the aging hypothesis that comes with MCT oil that is well documented and well known.

Brain Hypo-metabolism Illustrated (from Research Paper)

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