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Cherry Juice? Tart Cherry Extract is a sour cherry juice that has large amounts of anthocyanins compared to other cherry juices such as black cherry juice.

Anthocyanins may promote anti-inflammatory responses in the body. These compounds may be on par with Ibuprofen without the same side effects. 

NSAIDS (Non-Steroidal Anti-Inflammatory Drugs) are the standard treatment for inflammation and muscle pain, they can cause serious side effects, such as gastric bleeding, heart attack and kidney failure.

Tart Cherry compounds can switch genes on and off, thus is a form of epigenetic food, modulating things like tumor necrosis factor. This is a compound really worth investigating.

Inflammation is considered the master cause of many health problems and aging related disorders.

Though many fruits provided flavonoids. Anthocyanins are a particularly powerful class of them. Tart Cherry Extract contains high concentrations of many novel anthocyanins absent from other anthocyanin foods such as blueberries and bilberries, making this even more unique.

Though I don't like the term "superfood" this is a candidate for the label in many health circles.

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“Looks legit for NSAID replacement at least.

Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial

Pain associated with acute muscle injury is most likely due to oxidative tissue damage which leads to an inflammatory response, causing further production of free radicals and augmenting secondary muscle soreness 

The relative post-race reduction in pain in the cherry group (25 mm lower VAS than placebo) suggests that tart cherry juice provided a protective benefit against the acute muscle pain caused by distance running.

Due to methodological limitations, our results should be interpreted with caution. One limitation to the study was the subjective of assessment of pain by participants. However, the VAS is commonly used to determine acute levels of pain and has consistent and well-defined clinically meaningful thresholds



Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats

When examining cognitive performance, tart cherry-fed rats exhibited improved spatial working memory that was not observed in the control rats. Specifically, trial 2 latencies were significantly less than trial 1, showing that rats in the tart cherry group demonstrated one-trial learning, even with the 10-min retention interval. This one-trial learning was not found in the control group. Studies using aged animals and aging models have reported that daily consumption of polyphenol-rich foods improves spatial learning and memory performance

Even though tart cherry had significant beneficial effects on cognition, inflammation, and autophagy, the sample size in this study is too small to generate a meaningful analysis linking biochemical changes to behavioral outcomes.

The major findings from this study were that supplementation with tart cherry: (1) transiently increased food intake without affecting body weight; (2) had no effects on motor function; (3) improved spatial learning and working memory; and (4) reduced inflammation and promoted autophagy in aged rats.

Effects of powdered Montmorency tart cherry supplementation on acute endurance exercise performance in aerobically trained individuals

Tart cherry ingestion reduced post-run serum markers of muscle catabolism, secondary muscle damage, and physiological stress over the 48-h recovery period compared to the placebo. Decreased muscle catabolism and stress are indicative of the attenuated recovery inflammatory response reported with tart cherry supplementation versus placebo. Antioxidant activity in those who ingested tart cherry was greater than the placebo, particularly 24 and 48-h post-run.

“Is this university reputable? Anyways evidence for fat loss and obesity maybe...

Benefits of Tart Cherry Extract

Most the benefits of Tart Cherry Extract can be attributed to its excellent anti-inflammatory properties. Anti-inflammation is really good for anti-aging as well as inflammation tends to get harder to control and more widespread as we age.

1. Reduce Inflammation and Arthritis Pain

The antioxidants in Tart Cherry Extract can reduce pain and inflammation from osteoarthritis (R) . A research demonstrated drinking cherry juice twice a day for 21 days reduced the pain for people with osteoarthritis, less inflammation in their blood too.

2. Protects Your Muscles from Damage

As we get older, our muscle mass and strength gets weaker, unfortunately, this is known as sarcopenia. Whilst exercise can help overcome this process, older people also tend to recover slower from exercise.

Research has shown that oral ingested Anthocyanins from tart cherries significantly lowered inflammation-related pain in rats, depending on the dose. The higher the dose the more pain was reduced. Exercise-induced damage was also reduced. This was then verified in humans for muscle recovery too, so the research is plenty.

Across the board reduction in inflammation helped muscle recovery. Faster knee recovery was also documented.

3. Helps Fat Loss by Reducing Inflammation

Chronic inflammation just sucks, it increases a number of problematic conditions that only get worst with age, including cancers and heart disease. Obesity is also a contributing factor, and a consequence of obesity.

It has been found that adipose tissues are constantly active and generate pro inflammatory signals called cytokines.

Research has shown that obese adults who consumed 8 ounces daily of tart cherry juice for 4 weeks showed significantly lowered inflammation, therefore regulating metabolism of fat.

4. Reduces Cancer Growth

Anthocyanins in Tart Cherry Extract have been found to switch off genes involved in the pathways of cancer cell proliferation, and angiogenesis.

Anthocyanins can also trigger apoptosis, programmed cell death that causes pre-cancerous cells to die.

Research establishes that anthocyanins work through a network of mechanisms to promote general anticancer protection due to a synergy between Anthocyanins and Phenolic Acids in Tart Cherry Extract. Research is still ongoing for this.

5. Cardiovascular Protection

A series of studies on rats showed that diets with Tart Cherries reduced cardiovascular disease risk. These are because of a reduction in cholesterol, body fat, weight and abdominal fat ( the fat loss effects). Again inflammation is linked to heart disease risk>

Impressively, in mice with Tart Cherry Extract, there is a 26% decrease in cholesterol and a 65% reduction in early death.

6. Protects the Brain

The mixture of generally great anti-oxidants in Tart Cherry Extract, has also resulted in studies that they protect neurons from cell-damaging oxidative stress.

This is a general anti-oxidant benefit though and requires further research to prove. In general the NSAID like effects are the most interesting for Tart Cherry Extract.


Mechanism of Action

Works on many biochemical pathways. Inhibits COX-1 and COX-2 enzymes which make inflammatory chemical signals called prostaglandins.

Suppresses nuclear factor-kappaB activation in white blood cells.

Switches off genes linked to cancer and inflammation. Switches on cell death of pre-cancerous cells?

Prevent Lipoprotein peroxidation that leads to endothelial damage.

Targets cholesterol and triglycerides, controls blood glucose levels, boost detoxifying enzymes and natural body antioxidants like gluthathione peroxidase and superoxide dismutase. Lower blood levels of uric acid.

Perhaps most importantly causes a pain relief effect, reduces oxidative stress, neurodegeneration and tumorigenesis.

Please note that the pro-supplement industry may be over exaggerating the benefits of this fruit extract. Whilst there is a ton of research on it, I am skeptical of anything that is a miracle cure all.

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