Are you using niacin or nicotinamide riboside? If so, watch this video! These supplements can help you age more gracefully and give you more energy, but they can also hurt your liver, mess with your neurotransmitters and your mood, and even sap your energy. In this video I discuss using a powder for better control …
“Research showing oral ingestion may simply CONVERT to NICOTINAMIDE in circulation, but injection would work to increase NR substantially, that NR works BETTER than NMN in assimilation into muscle.
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
The active formation of liver NAD from NR and NMN is consistent with both compounds being subject to substantial hepatic first pass metabolism. In contrast, extrahepatic tissues displayed minimal M+2 NAD (Figure 2.7e), suggesting that orally delivered NR and NMN are converted into NAM before reaching the systemic circulation. IV injection of NR or NMN, on the other hand, resulted in substantial M+2 NAD in both liver and kidney. In the brain, we detected only M+1 NAD, indicating a reliance on circulating NAM and 34 suggesting that intact NR and NMN may not cross the blood-brain barrier. Interestingly, NR but not NMN was efficiently assimilated intact into NAD in muscle. To our knowledge, this is the first clear example of a differential metabolic effect between these two compounds in vivo.