Prostaphane for Aging Prostate


Introduction

It has been recognized that there needs to be a greater focus on Men’s Health especially in the field of Sexual and Reproductive Health. Women in general have better health seeking behaviour and will seek out health information, get screened for chronic diseases and have early interventions to correct or stall the development of diseases.

The prostate gland in men is a part of the reproductive organ. It produces a third of the fluid that nourishes the semen during ejaculation. It is located below the urinary bladder and the gland envelopes the urethra which is the pipe through which urine and semen flow.

The prostate gland can be affected by the following diseases

  • Prostatitis
  • Benign Prostatic Hyperplasia
  • Prostate Cancer

 

What is Prostaphane?

Broccoli-derived sulforaphane has been studied for chemoprevention of prostate cancer. The patented formula is Prostaphane. It is prescribed for men over the age of 45 years old who report signs and symptoms of what we call an aging prostate.

The anti-inflammatory and anti-oxidant effect of the active sulforaphane has a protective action at the cellular level for not only the prostate but also the bladder.

Prostate Cancer and Diet

Prostate cancer is the development of cancerous cells in the prostate gland.

The risk factors for prostate cancer are:     

  • Age: Men age 65 years and over are at greater risk of prostate cancer.  
  • Ethnicity: There is a higher incidence of prostate cancer among African-American men when compared to white men    
  • Family history: brothers and sons of men diagnosed with prostate cancer are at increased risk of developing prostate cancer.    
  • Diet: The diet can be one of the risk factors for prostate cancer. A high fat diet may increase the risk of prostate cancer.

 

Broccoli and Sulforaphane

The protective effect of fruits and vegetables on most cancers is very well established. Sulforaphane seems to correlate with reduced risk of prostate cancer. Consumption of broccoli seems to correlate with reduced risk of prostate cancer.

Nutritional scientists recommend daily consumption of Cruciferae vegetables namely:

ü Broccoli

ü Cauliflower

ü Brussels sprouts

Several epidemiological studies have suggested that eating cruciferous vegetables, such as broccoli can decrease the risk of prostate and bladder cancers.

Mechanism of action

When broccoli is consummed it interacts with the Glutathione S-transferase Mu 1 GSTM1 to disrupt oncogenic signalling pathways in the prostate. In other words, it detoxifies electrophilic compounds including carcinogens and the by-products of oxidative stress by bonding with glutathione

This is the singularly most important protective action that reduces the development of prostate cancer.

 

Research Papers

  1. Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency

JW Fahey, KL Wade, SL Wehage. Molecular nutrition & …, 2017 - Wiley Online Library. This supplement, Prostaphane® (Nutrinov, Noyal sur Vilaine Cedex, France), was used in a well‚Äźdocumented multicenter prostate cancer prevention study 51.

 

  1. Broccoli-derived sulforaphane and chemoprevention of prostate cancer: from bench to bedside

AI Amjad, RA Parikh, LJ Appleman, ER Hahm… - Current pharmacology …, 2015 - Springer

Completed studies. Cipolla et al. [55]. Randomized double-blind placebo-controlled multicentre (France). Patients with PSA relapse after prostatectomy. (n = 81). 60 mg (340 μmol) “stabilized SFN” (Prostaphane®) daily for 6 months vs. matched placebo

 

  1. Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach

A Leone, G Diorio, W Sexton, M Schell, M Alexandrow… - Oncotarget, 2017 - ncbi.nlm.nih.gov

 

  1. Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas

K Canene-Adams, BL Lindshield, S Wang, EH Jeffery… - Cancer research, 2007 - AACR Publications: Cancer Discovery; Cancer Epidemiology, Biomarkers & Prevention; Cancer Immunology Research; Cancer Prevention Research; Cancer Research; Clinical Cancer Research; Molecular Cancer Research; Molecular Cancer Therapeutics 

 

  1. Health benefits and possible risks of broccoli–an overview

KP Latté, KE Appel, A Lampen - Food and Chemical Toxicology, 2011 - Elsevie

 

  1. Lycopene effects contributing to prostate health

K Wertz - Nutrition and cancer, 2009 - Taylor & Francis

Canene-Adams K, et al.: Combinations of tomato and broccoli enhance antitumor activity … Punab M: Prevalence of asymptomatic inflammatory (National Institutes of Health Category IV … pathway:
a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells. 

 

  1. Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate

M Traka, AV Gasper, A Melchini, JR Bacon, PW Needs… - PloS one, 2008 - journals.plos.org

  1. Carotenoids and human health

AV Rao, LG Rao - Pharmacological research, 2007 - Elsevier

 Broccoli, cooked, 1839 … These observations suggest a possible biphasic response of β-carotein that promotes health when taken at dietary levels, but may have … Testes, adrenal glands, prostate,
breast and liver were shown to have the highest levels of lycopene in humans. M Traka, AV Gasper, A Melchini, JR Bacon, PW Needs PloS one, 2008 - journals.plos.org

  1. Research Article. Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate. Maria Traka, Affiliation Phytochemicals and Health Programme, Institute of Food Research, Norwich Research Park, Norwich, United Kingdom 

 

10.Diet and prostate cancer: mechanisms of action and implications for chemoprevention

V Venkateswaran, LH Klotz - Nature Reviews Urology, 2010 - nature.com

Vasundara Venkateswaran and Laurence H. Klotz Abstract | As one of the most prevalent cancers, prostate cancer has enormous public health significance and prevention strategies would attenuate its economic, emotional, physical and social impact

 

News

These are exciting development in the research findings to rejuvenate the aging prostate. Prostaphane has both preventative and therapeutic impact on the prostate with respect to prostatic cancer cells.

Another ground-breaking research being used by rejuvenation specialist is the use of stem cells and plasma rich plasma to regenerate aging organs. The prostate gland is finally getting less invasive alternatives to surgery.

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